From AI research labs to cross-border factories, global businesses are discovering that Singapore is a trusted foundation from which to scale across Asia.

Southeast Asia’s economies now represent a combined market of more than 680 million consumers. Yet, capturing that opportunity is rarely a straight line. Against the backdrop of contrasting regulatory regimes, uneven data infrastructure and supply chain vulnerabilities, the question for international C-suite decisionmakers is no longer whether to expand but how to do so without unnecessary operational risk.
In 2025, Google DeepMind established its first Southeast Asian research lab in Singapore, while Barry Callebaut opened a Global Innovation Center there earlier this year, housing its first global AI Center of Excellence. Both companies, while operating in different industries, arrived at the same conclusion: Singapore offers a sound base for innovation and growth into the region.
That ability to build outward rests on structural advantages that let companies plan not just quarters but years ahead. Singapore combines a strategic location with an expanding web of bilateral and regional economic frameworks, giving companies the confidence to commit manufacturing, supply chains and operations beyond a single market.
Trust as Infrastructure
Ask executives why they anchored their most sensitive work in Singapore and one word recurs: trust. Dependable rule of law, strong intellectual property protection and consistent, business-friendly governance give companies the confidence to house not just back offices here but proprietary technology and long-horizon research.
That trust is part of a broader competitive proposition: Singapore reclaimed the top spot in the IMD World Competitiveness Ranking for 2026, reflecting an institutional environment that keeps pace with innovation across finance, healthcare, advanced manufacturing and now AI—giving companies the latitude to pursue more ambitious, higher-value work.
Nowhere is that trust more consequential than in AI. For multinational innovators, the high stakes of AI force a difficult choice: move fast to capture growth or build the deep local connections needed to create lasting impact. Rarely can they do both. That is precisely why Microsoft chose Singapore as the home of Microsoft Research Asia’s (MSRA) first AI research lab in Southeast Asia, following an evaluation process that stretched well over a year.
“A key differentiator is Singapore’s ‘fullstack’ AI talent pool,” says Dr. Lidong Zhou, Corporate Vice President of Microsoft and Managing Director of Microsoft Research Asia. “The workforce demonstrates deep research expertise, strong engineering capability and multilingual, cross-cultural fluency. Singapore also produces highly adept practical implementers who can translate foundational models into reliable, resource efficient solutions for demanding industries like healthcare, finance and logistics.”
Government-backed pipelines such as the Singapore Economic Development Board’s (EDB) Industrial Postgraduate Programme (IPP) help sustain that talent stream while policies like the National AI Strategy 2.0 and the AI Verify Foundation’s Testing Framework and Toolkit—now referenced by companies and regulators internationally—give global technology firms the regulatory clarity to research and deploy sensitive, proprietary systems with confidence.
“A key differentiator is Singapore’s ‘full-stack’ AI talent pool. The workforce demonstrates deep research expertise, strong engineering capability and multilingual, cross-cultural fluency.”
– Dr. Lidong Zhou, Corporate Vice President, Microsoft Research Asia
Strong Partnerships That Spur Innovation

For Microsoft, this confidence has been built through years of partnerships with Singapore’s universities and industries. Together with partners across Singapore’s healthcare ecosystem, MSRA is exploring multimodal and agentic AI approaches to support clinical decision making, unlock insights from complex medical data and advance research in disease diagnosis, risk assessment and personalized care. It also collaborates with the National University of Singapore (NUS) on spatial and embodied intelligence, advancing benchmarks that integrate perception, language and action for complex manipulation tasks.
These partnerships reflect the broader ecosystem Singapore has built to connect global technology companies with research institutions, industry expertise and talent—helping companies scale AI responsibly from research to real-world applications across the region. That same ecosystem supports R&D across industries.
German specialty chemicals group Evonik has made Singapore one of its most significant Asian outposts, since the establishment of its first office in 1969. Today, Singapore is home to Evonik’s Asia-Pacific regional headquarters, its first Asia Research Hub, and live manufacturing plants across Jurong Island and Tuas.
Evonik owns and operates the world’s largest manufacturing complex for DL-methionine, an essential amino acid for animal nutrition, on Jurong Island. More recently, Evonik further expanded its manufacturing footprint with the opening of a world-scale alkoxides production facility on Jurong Island to serve growing demand across Asia in areas such as biodiesel, pharmaceuticals and chemical recycling. Evonik’s R&D presence in Singapore is also deeply extensive, covering topics across sustainability, novel materials, life sciences, skin sciences and more.
For Evonik’s Singapore-based Deputy CEO and Asia-Pacific President Claus Rettig, these diverse activities all point to a broader regional strategy. He says, “Asia is central to Evonik’s growth strategy. Our ambition is to increase the region’s contribution from around a quarter of global sales today to one-third by 2032. To achieve this, we are strengthening our presence across the region by investing close to our customers and building on the distinct capabilities of markets such as China, India, Japan, South Korea and Southeast Asia. This regional network enables us to respond faster to customer needs while creating a more balanced and resilient global footprint.”
“Asia is central to Evonik’s growth strategy. Our ambition is to increase the region’s contribution from around a quarter of global sales today to one-third by 2032.”
– Claus Rettig, Deputy CEO and Asia-Pacific President, Evonik
Connectivity That Unlocks Value

The Johor-Singapore Special Economic Zone (JS-SEZ) offers a simple but powerful proposition: Singapore’s connectivity, capital and regulatory certainty paired with Johor’s land, labor and cost advantages. Together, they create something neither side could build alone.
The numbers tell the story. Since early 2024, Singapore-based companies have committed over S$5.5 billion (US$4.3 billion) to Johor. The pipeline spans advanced manufacturing, agri-tech and data centers—with global names across medtech, logistics and specialty chemicals exploring cross-border operations. What unites them is a shared logic: keep R&D, product development and regulatory a airs in Singapore; scale production and fulfillment in Johor.
U.S.-headquartered Resmed demonstrates how Singapore’s advanced capabilities and connectivity can support global growth. The health technology company has built a significant presence in Singapore, including its Tuas Advanced Manufacturing Centre, which produces leading devices such as the AirSense 11. That footprint complements Resmed’s manufacturing operations in nearby Johor, creating an integrated regional model that combines capabilities across both locations.
Nigel Cheong, Resmed’s Director for Manufacturing and Logistics, describes the approach as striking “the right balance between cost effectiveness, resilience and synergy between Singapore and Johor.”
Proximity is a key advantage. It gives Resmed greater flexibility to move people, knowledge and expertise across its operations while strengthening the resilience of its regional footprint. As connectivity between Singapore and Johor deepens, Resmed offers a compelling example of how global companies can leverage Singapore as a strategic hub, tap complementary capabilities across Southeast Asia and build operations designed to scale globally.
“Resmed’s approach strikes the right balance between cost-effectiveness, resilience and synergy between Singapore and Johor.”
– Nigel Cheong, Director for Manufacturing and Logistics, Resmed
Engineering Resilience Across Borders

DHL and Kuehne+Nagel show how Singapore’s trade infrastructure and connectivity extend the same logic into logistics. Both have built operations spanning Singapore and Johor, using the city-state’s professional and regulatory ecosystem to run time-critical, high-value operations while tapping Johor for scale.
For DHL, Singapore’s data infrastructure and connectivity make it possible to see where supply chains can work more efficiently across the region. Its Connected Control Tower (CCT) uses real-time tracking and predictive analysis to uncover inventory gaps and inefficiencies, revealing optimization opportunities companies may not have realized, from freeing up capacity to reducing working capital tied up in inventory.
Kuehne+Nagel has built a similar hybrid model: seven sites in Singapore—including its Asia-Pacific headquarters and five fulfillment centers spanning more than 85,000 square meters—handle time-critical, high-value cargo while two sites in Johor manage cost sensitive, scalable activities.
Despite the Causeway’s status as one of the world’s busiest land crossings, Kuehne+Nagel’s Peer Rasmussen, Managing Director for Singapore and Malaysia, challenges the assumption that congestion limits cross border operations. “Procedures have become noticeably faster and more efficient,” he says. “In reality, with proper planning, cargo movements can be managed smoothly.”
“Procedures have become noticeably faster and more efficient. In reality, with proper planning, cargo movements can be managed smoothly.”
– Peer Rasmussen, Managing Director for Singapore and Malaysia, Kuehne+Nagel
That same connectivity is extending into healthcare and pharmaceuticals. DHL has opened a 10-million-euro (US$11.6 million) Pharma Hub in Singapore, part of a 500-million-euro (US$578.5 million) regional commitment to life sciences and healthcare, purpose-built for cold-chain pharmaceutical distribution.
Kuehne+Nagel operates its own 50,000-square-meter logistics hub near Singapore’s healthcare cluster, with more than 65% configured for advanced cold storage, redressing and postponement. The facility supports temperature-controlled distribution of pharmaceutical and medtech products across the border, including Thailand.
But connectivity is not simply about moving goods; it is about opening markets. For DHL Supply Chain Southeast Asia CEO Edwin Wong, the strategic advantage of Singapore’s 29 free trade agreements (FTAs) is clear: “Given the current state of global trade, these FTAs enhance our customers’ trade opportunities, offering them greater flexibility for both importing and exporting goods.”
“Given the current state of global trade, these FTAs enhance our customers’ trade opportunities, offering them greater flexibility for both importing and exporting goods.”
– Edwin Wong, Supply Chain Southeast Asia CEO, DHL

The Long View
What connects Microsoft’s researchers, Evonik’s scientists, Resmed’s engineers and the logistics executives of DHL and Kuehne+Nagel is not a single incentive or accolade. It is the ability to combine capabilities that no single market could offer: innovation with application, highvalue operations with scalable capacity, and connectivity with resilience. That is not just a regional headquarters model. It is a strategy for growth that can adapt as the region evolves.
For companies building their presence across Asia, Singapore offers the stability to commit for the long term and flexibility to adapt as opportunities evolve. Its value no longer stops at its borders but rests in what companies can orchestrate from its infrastructure. That is the enduring advantage: the ability to plan for the long term without closing off the options tomorrow may demand.
Find out more at: edb.gov.sg/en/how-we-help/scale-across-southeast-asia

edb.gov.sg
